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Philip Norris, MD

Philip Norris, MD, is an associate investigator and director of immunology at Blood Systems Research Institute, a UCSF-affiliated research institute and a division of Blood Systems, a national blood bank; as well as adjunct assistant professor of laboratory medicine and assistant clinical professor of medicine at the University of California, San Francisco. Dr. Norris earned his BA and BS degrees from the University of California, Berkeley, and his MD degree from the College of Physician & Surgeons at Columbia University; and completed his residency in internal medicine at Duke University Medical Center and fellowship in infectious diseases at the Massachusetts General Hospital. Dr. Norris has received numerous academic awards and was the recipient of a Doris Duke Charitable Foundation Clinical Scientist Development Award in 2000. He currently serves as an associate director of the UCSF-GIVI Center for AIDS Research.

The Norris lab research interests focus on how the human immune system responds to viral infections, particularly HIV. Early efforts centered on defining how HIV-specific CD4+ T cells might contribute to control of viral infection. Norris demonstrated that these cells possess antiviral activity and are able to kill other virus-infected CD4+ T cells. Ongoing work is defining how HIV might escape these responses, with important implications for vaccine development. A second area of interest has been defining the earliest events of HIV infection through study of plasma donor panels and patients with acute HIV infection. Additional projects include methods to enhance the immunogenicity of natural HIV sequences through targeted mutation, with the goal of creating more effective HIV vaccine candidates.

 

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